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2014年2月21日 星期五

氫氣可治療耳聾


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氫氣能對抗內耳毛細胞氧化損傷-可治療耳聾?
中文摘要:
本文是氫分子醫學的第16篇文獻.

活性氧在老化、燥聲和藥物毒性引起的聽毛細胞退行性改變中具有重要作用。在生物體系中,氫化是氧化還原反應的基礎。本研究目的是研究氫氣對活性氧誘導的聽毛細胞損傷的潛在作用。研究採用antimycin A方法產生活性氧,觀察對體外培養的聽上皮細胞,並檢測氫氣對抗聽毛細胞活性氧的作用。結果發現,飽和氫溶液能顯著減少聽上皮細胞活性氧含量和脂質過氧化程度,提高聽毛細胞存活數量。該研究提示,氫對保護活性氧誘導的聽毛細胞具有潛在作用。
Neuroreport. 2009 May 6;20(7):689-94. Links



Hydrogen protects auditory hair cells from free radicals.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Reactive oxygen species (ROS) play a role in the degeneration of auditory hair cells because of aging, noise trauma, or ototoxic drugs. Hydrogenation is a fundamental reduction/de-oxidation reaction in living organisms. This study thus examined the potential of hydrogen to protect auditory hair cells from ROS-induced damage. To generate ROS, we applied antimycin A to explant cultures of auditory epithelia, and examined the effect of hydrogen on the protection of hair cells against ROS. Incubation with a hydrogen-saturated medium significantly reduced ROS generation and subsequent lipid peroxidation in the auditory epithelia, leading to increased survival of the hair cells. These findings show the potential of hydrogen to protect auditory hair cells from ROS-induced damage.
感谢DXY提供,
全文


Effect of hydrogen on the survival of cochlear hair cells. (ah) Photomicrographs of phalloidin (green) and myosin VIIa (red)-labeled cochlear cultures,treated with 0 (a and b), 0.1 (c and d), 1 (e and f), and 10 mg/ml (g and h) antimycin A (AM), with (b, d, f and h) or without (a, c, e and g) hydrogen gas(H2). Bar, 5 mm. IHCs, inner hair cells; OHCs, outer hair cells.

http://blog.sciencenet.cn/blog-41174-229111.html


資料來源 http://blog.sciencenet.cn/blog-41174-229111.html

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